They also influence the progression of hematologic diseases such as leukemia, multiple myeloma, and aplastic anemia, and may be a novel. Normal hematopoiesis is a wellregulated process in which the generation of mature blood elements occurs from a primitive pluripotent stem cell in an ordered sequence of maturation and proliferation. Understanding this process requires a comprehensive knowledge of both the anatomy and the physiology of the bloodforming system. Scribd is the worlds largest social reading and publishing site.
Hematopoiesis article about hematopoiesis by the free. Since basic cellular processes are similar for hematopoiesis, including lymphocyte development and reactions of mature lymphocytes i. The circulating blood cells are formed in bone marrow through a process called hematopoiesis. Figure 2 extramedullary hematopoiesisarrow indicates erythroid cells, and arrowhead indicates a megakaryocyte, in a. Computer modelling of hematopoiesis with applications to. Cells and organs of the immune system hematopoiesis hematopoiesis formation and development of wbc and rbc bone marrow. Conceptually, hematopoiesis in females can be viewed as a competitive exclusion process in which two populations of hsc defined by parental xchromosome phenotype compete for environmental resources. Furthermore, while cell numbers are maintained within fairly narrow limits, they can be greatly amplified on demand. However, these snapshot analyses only allow limited conclusions about the involved sequence of individual molecular and cellular events fig.
As in many ecological examples, dominance may occur only after long periods of time. Hematopoiesis, including lymphocyte development and maturation. Rbcs, wbcs and platelets is called as haematopoiesis and the sites where it occurs are known as hemopoietic tissues or organs bone marrow, liver, spleen cells responsible to do function of hemopoiesis are first seen in yolk sac of embryo in third week of embryonic development. Hematopoiesis is the production of all the blood cells including rbcs, wbcs, and platelets.
Figure 1 shows that all the cell types originate from a common precursor hematocytoblast. Hematopoiesis first appears around day 16 of gestation in the embryonic yolk sac. It is not generally found in other areas of the long limb bones. It happens naturally in the body, starting when a human is still an embryo. Motivation chemotactic hscs movement regeneration of blood system concluding remarks gergana bencheva, seminar on mathematical modelling, fmi, so.
View notes bio 349 hematopoiesis notes from exs 349 at university of north carolina, wilmington. Hematopoiesis basic concepts lecture 1 slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Bila memeriksa variasi fisiologi dan patologi selsel darah tidak hanya persentase tetapi juga jumlah absolut masingmasing jenis per unit volume darah harus diambil effendi, 2003. Diferensiatif mematangkan diri menjadi selsel dengan fungsifungsi tertentu. Treatment with cytokines in particular granulocyte colonystimulating factor. Figure 1 extramedullary hematopoiesisarrows indicate erythroid cells in a female harlan spraguedawley rat from a chronic study. Hematopoiesis merupakan proses produksi mengganti sel yang mati dan perkembangan sel darah dari sel induk asal stem sel, dimana terjadi proliferasi, maturasi dan diferensiasi sel yang terjadi secara serentak. Fisiologi sistem endokrin 4 struktur dasar hormon secara kimiawi derivat asam amino dikeluarkan oleh sel kelenjar buntu yang berasal dari jaringan nervus medulla supra renal dan neurohipofise, contoh epinefrin dan. A free powerpoint ppt presentation displayed as a flash slide show on id. During embryonic development, this function is performed mainly in the spleen, liver and bone marrow, and after the birth the production of these elements is performed mainly by the bone marrow and the lymph nodes. Hematopoiesis, the latest volume in the current topics in developmental biology, covers hematopoiesis, with contributions from an international board of authors. Hematopoiesis is the process that generates blood cells of all lineages 1. Pendahuluan 20 l cairan plasma difiltrasi keluar menuju bagian interstisial, 17 l direabsorpsi oleh. Introduction hematopoiesis refers to all aspects of the process of blood cell production.
Proliferasi sel menyebabkan peningkatan atau pelipat gandaan jumlah sel, dari satu sel hematopoietik pluripotent menghasilkan. Developmental hematopoiesis where does it occur when before birth. Gambar selsel darah dalam hematopoiesis colour atlas of hematology, practical microscopic and clinical diagnosis, oleh harald theml,m. For example, how selfrenewal potential is maintained in hscs is still not understood. The first of such stem cell lines forms in the mesoblast extraembryonic mesoderm of the umbilical vesicle stage 7, ca. Fungsi dari sel darah merah adalah oksigenansi jaringan dengan transport. Hematopoiesis is usually analyzed in heterogeneous populations and at individual time points of the process of interest. Hematopoiesis the process by which blood cells are formed has been studied intensely for over a century using a variety of model systems. Bio 349 hematopoiesis notes hematopoiesishemopoiesis. The hematopoietic system is formed by bodies responsible for haematopoiesis, or the production of the cellular elements of blood. This stem cell is called the pluripotential pluripotent stem cell. Pdf erythropoietin is a glycoprotein hormone produced by kidney and functioning as regulator for eryhtropoietic processes. It refers to the formation of blood cellular components.
Most work in the field has focused on events occurring in the adult bone marrow bm. Hematopoiesis research is the leading field in stem cell biology because experimental systems have already been established and hscs can be purified relatively easily by facs sorting. Unduh sebagai pptx, pdf, txt atau baca online dari scribd. Regulation occurs at the level of the structured microenvironment. Professor,newyork 2004, hal 23 sel ini sedikit lebih besar daripada eritrosit matur, berada selama 12 hari dalam sumsum tulang dan juga beredar di darah tepi selama 12 hari sebelum. Hematopoiesis from multipotent stem cells thermo fisher. This is found in birds with possible analogous tissue in man, responsible for normal antibody precursor. Introduction to hematologyhematopoiesis tuesday, february 10, 2004 9. In a healthy adult person, about 10 11 10 12 new blood cells are produced daily to keep steady state levels in the blood circulation hematopoietic stem cells hscs or hemocytoblasts are the stem cells that give rise to all the other blood cells. Berdasarkan kondisi tersebut, karena b adalah fungsi yang positif. Sites of hematopoiesis depend on the presence of disease and on the developmental state of the individual.
Pleuripotent stem cells can give rise to all types of blood cells and many other cell types, as well. If you continue browsing the site, you agree to the use of cookies on this website. Overview of hematopoiesis questions and study guide. Haematopoietic stem cells reside in the medulla of. Hematopoiesis in the fetus occurs in multiple organs besides the bone marrow, including the thymic anlage, primordial lymph nodes, liver, spleen, kidney, and adrenals valli, 2007. Understanding this process requires a comprehensive knowledge of both the anatomy and the physiology of. Today one assumes that all the cells of the hematopoietic system stem from a stem cell line. The three main types of cells are the red cells erythrocytes, which serve to carry oxygen, the white cells leukocytes, which function in the prevention of and recovery from disease, and the thrombocytes, which function in.
There is conservation of the overall hematopoietic process between vertebrates, although some differences do exist. Unraveling how hematopoiesis is maintained and regulated has provided a paradigm for understanding the biology of tissue stem cells and has resulted in the development of effective therapies for certain cancers and genetic disorders as well as a variety of conditions in which bone marrow output is inadequate to maintain normal blood cell counts. Fetal hematopoiesis definition of fetal hematopoiesis by. The bone marrow has an enormous production capacity. Hematopoiesis, the process of blood cell formation, is orchestrated by cytokines and growth factors that stimulate the expansion of different progenitor cell subsets and regulate their survival. Hematopoiesis hemopoiesis hemocytoblasts could give rise to all blood cells, depending on. Hematopoiesis is the formation and development of blood cells. Bone marrow bm is the major site of hematopoiesis in humans and, under normal condtiions, only smal nl umbers of hematopoei tic stem and progenitor cells hspcs can be found in the peripheral blood pb. Unduh sebagai docx, pdf, txt atau baca online dari scribd.
Red marrow can be found in vertebrae, ribs, skull, sternum, scapula, and proximal ends of the limb bones known as the trabecular area. The currently accepted theory on how this process works is called the monophyletic theory which simply means that a single type of stem cell gives rise to all the mature blood cells in the body. Oscillations in mathematical models of hematopoiesis process indicate that hematopoiesis occurs unstable. At birth hematopoiesis is restricted primarily to the marrow, although occasional areas of extramedullary hematopoiesis may be found in the spleen or liver. In the embryo and fetus it takes place in a variety of sites including the liver, spleen, thymus, lymph nodes, and bone marrow. Hematopoiesis pathophysiology of blood disorders, 2e. As the rbcs and platelets have a limited life span, they need to be replaced continuously.
Over the last decade, the zebrafish has come to the forefront as a new model in. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Hematopoiesis is the process by which immature precursor cells develop into mature blood cells. Normal conditions originate in the bone marrow some components e.
Hematopoiesis hematopoiesis hematopoiesis apoptosis. The process by which the cellular elements of the blood are formed. Hematopoiesis is the process of creating new blood cells from stem cells. Kata anatomi berasal dari bahasa yunani yang berarti memotongmotong ahli anatomi mempelajari hubungan antara bagian tubuh sebagai bagian truktur suatu individu. The process whereby the blood cell components red blood cells erythrocytes or rbcs, white blood cells leukocytes or wbcs, and platelets thrombocytes are produced in the body. All cellular blood components are derived from haematopoietic stem cells. Experimental data can then usually be explained by a multitude of hypotheses.
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